I bought the S550 4 pistons also. Even with light grinding, couldn't
get them to fit with my wheels unless I used at least a 3/8 spacer.
They stick out a good 1/4 inch more (vs WMS) than the Chinese castings
(never did measure the Ford Brembos).
Yep exact same issue I ran into. Now granted I am running S550 wheels which have weird backspacing/offset, but I only had to run a 7 or 8mm spacer to clear the Brembos with them. The S550 calipers were going to require, as you said, 3/8" or 1/2" spacers to clear and I didn't want to install longer studs so I abandoned that idea. With the Brembos I just ran ET (extended thread) style lugs and it all works just fine.