Just a quick update, got some smoke coming out of the tailpipes now and compression in #8 is down......
Just kidding, everything's great. The last fill-up I tried 5 gallons of e85 in the tank this time (I had run two tanks of pure gas in it for a long road trip so there was basically zero e85 in it previously), so this time it was basically a 30% e85 / 70% gasoline mix, and I see no benefit as far as knock resistance with this mix versus the 20% mix. So this basically confirms what "cbrtx" said above, keep it at 20% or so and get the benefits with the least amount of fuel trim adjustment.
Fuel trims are about +10% with the 30% mix versus around +7-8% with the 20%, both of which are what I expected.