I have used nitrous (dry and wet systems; plate & foggers) for many, many years and have learned a few things... spark plugs, fuel system, proper timing, auto activation, bottle temps... but the most important thing I have learned is WOT use is essential! Part-throttle use can lead to backfiring and puddling inside the intake manifold.
Being you have an automatic you might be able to use a button activation, but in reality a RPM activation switch or progressive controller should be used just to make things simpler and you as the driver can focus on the car and less on pressing & depressing a button.
I have to ask, did you buy a brand-new kit designed for your application or are you pulling parts together to do your own custom set up? Nothing wrong with either one, but mixing and matching systems, solenoids and jets could be problematic... Also, some racing bodies mandate a blow offline/discharge tube and N2O lines must be routed outside the car and not through the interior. Guilty as charge! LOL
Remember, 4.6 3V intakes are plastic, the CM plates are thin metal, MAF are sensitive, etc. You could damage something with a simple backfire. This is all repairable (for the most part) but understanding there might be some hiccups until you get things dialed in.
I have seen and heard of engines being damaged by N2O (head gasket, piston or rod damage) which usually occur after constant abuse or over revving, missing a gear with a manual trans while at high RPM and using big HP of nitrous being activated.
Enjoying juicing and the bottle gets empty very quickly especially at high HP numbers.