Define safe lol. E85 is very corrosive to rubber hose in general, but in the scheme of things however this is the best hose on the market to use with it. It will eventualy breakdown, which it will do in gas as well it will just take alot longer than a lesser quality hose. I will put it this way though, the hose will most likely outlive the car. I have quite few guys running my setups with e85 and I exclusively use gates 30r10 sae hose for this reason.
"The Gates Submersible Fuel Line Hose contains a special compound called Fluoroelastomer (FKM), which resists gas permeation and retards aging. It is also reinforced with Aramid Fiber—the same fiber used in bulletproof vests and that is pound for pound stronger than steel. It is this advanced construction that allows the Gates Submersible Fuel Line Hose to exceed the SAE 30R10 rating, which is the standard for a submersible fuel line hose application. It also makes the Gates Submersible Fuel Line Hose the perfect hose for submersed in-tank applications."