Unwrap the harness. Unhook connectors or cut wires. Reroute however you like and reconnect or solder wires. Re-wrap harness. Depending on how you route them you may need to extend some of the wiring. Just do it methodically, maybe even one wire or set of wires at a time.
Aren't the wires behind the plastic wheel tubs? Or do you have them removed? If I remember correctly they are tucked right along the inner fender. I added another loom in there when I was removing wires from the engine bay and adding gauges and stuff. Can't see a tire rubbing on them without hitting something else first, but maybe I'm completely wrong, it's been awhile since I had the little tubs off.