A vacuum pump is completely different than a PCV system. PCV Systems were created for emissions purpose.
Vacuum pumps do help with the efficiency of the engine during loaded/WOT conditions where you want to pull enough vacuum to overcome crankcase pressure, and assist with a better ring seal. The ring sealing benefit, is what helps performance. In a non vacuum manifold situation, a vacuum pump will also help remove blow-by / vapors better as well. In a perfect world, a regulated vacuum pump is the best method for a gearhead.
In a non loaded/WOT situation, the PCV system is doing all of it's work. In these conditions (normal driving) is when the PCV system and oil separators etc work their hardest, because manifold pressure is going to be significantly less (more vacuum) than the crankcase pressure - hence the reason why these were implemented for emissions purpose.
In loaded situations - the manifold pressure rises, and once that pressure differential (manifold VS crankcase) favors the higher pressure side of the manifold, the PCV system is practically useless. If you have blow by, which we all do, it will contaminate your crankcase just opposite of the reason it was designed.
After toying with all of these PCV mods, I have simply gone to dual breather tanks on my past several cars. I run the largest fittings and lines (-12) that I can from each valve cover into the front fenderwells into their own tank.
The comment above about changing the oil with breathers is 100% accurate. If you spend a lot of time putting commuting miles on the car, you will definitely want to change the oil much more frequently.
To touch on my specific combos - I use E85 100% of the time in my cars. I primarily race my cars, and I beat on them hard when not racing. In an E85 specific application, I feel that real breather systems are more effective due to the ethanol's ability to absorb moisture/water. When I drain my tanks, they pour water out. A lot of it. In a sealed system, that moisture is building up inside the crankcase and lines, separators, etc.