Just my $0.02 and this is one of those topics but...No point to removing modern cats. On older cars, sure, some, but on these? Not worth it.
If you're doing a lot of aggressive mods that change the airflow (pressure) having or not having cats isn't the issue. (It's a bit like changing the intake requirement and seeing a difference with or without the stock air filter in...the presence of a filter isn't the issue, it's the wrong filter/intake for the job.)
On a stock or normally-modified engine, the car won't do any noticeable difference better and will have problems as the readings will be wrong. 02 sensors help the computer understand how the combustion is doing. If you tune it to compensate, still not worth it. You can fiddle with the tuning to calm things down, but that's not getting you a gain.
Only normalcy in not having cats is basically full-time race cars, and that's a different reason entirely. The whole "delete your cats and you'll make more power" thing is just noise.
The 05-10 Mustangs came with decent cats. This is an area where manufacturers work on their fuel efficiency numbers, so they're not going to put things in that tank the car.
You'll only have an issue if they're bad, and it takes quite a while for a cat to go bad normally (unless you don't take care of it). Best all around approach if you actually do have a bad cat, or upgrade your exhaust, is to replace with 'high-flow' cats (which even then is kind of a meh-increase) and you'll be good.